Intersting : There was once a woman who had immortal cells.

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Just seen this and thought it was pretty interesting :



Today I found out there was once a woman who had immortal cells. These immortal cells have multiplied to the point that if you were to weigh all of them that live today, they’d weigh about 50 million metric tons, which is about as much as 100 Empire State Buildings.

So who was this woman and why are scientists keeping about 50 million metric tons of her cells supplied with fresh nutrients so they can live on? The woman was Henrietta Lacks and her immortal cells have been essential in curing polio; gene mapping; learning how cells work; developing drugs to treat cancer, herpes, leukemia, influenza, hemophilia, Parkinson’s disease, AIDS… The list goes on and on and on. If it deals with the human body and has been studied by scientists, odds are, they needed and used Henrietta’s immortal cells somewhere along the way. Her cells were even sent up to space on an unmanned satellite to determine whether or not human tissue could survive in zero mavity.

Go to just about any cell culture lab in the world and you’ll find billions of Henrietta’s cells stored there. What’s unique about her cells is that, not only do they never die, in contrast to normal human cells which will die after a few replications, but her cells can also live and replicate just fine outside of the human body, which is also unique among humans. Give her cells the nutrients they need to survive and they will live and replicate along forever, apparently (almost 60 years and counting since the first culture was taken). They can even be frozen for literally decades and later thawed and they will go right on replicating.

Before her cells were discovered and widely cultured, it was nearly impossible for scientists to reliably experiment on cells and get meaningful results. Cell cultures that scientists would try to study would weaken and die very quickly outside the human body. Her cells gave scientists, for the first time, a “standard” that they could use to test things on. Even better, her cells can survive being shipped in the mail just fine, so scientists across the globe can all use the same standard from which to test against.

Henrietta Lacks herself was an impoverished black woman who died on October 4th, 1951 of cervical cancer at the age of just 31 years old. It was during getting her cancer treated that a doctor at Johns Hopkins took a sample of her tumor without her knowledge or consent and sent it over to a colleague of his, Dr. George Gey; Dr. Gey had been trying for 20 years, unsuccessfully, to grow human tissues from cultures. A lab assistant there, Mary Kubicek, discovered that Henrietta’s cells, unlike normal human cells, could live and replicate outside the body.

Henrietta died of uremic poisoning, in the segregated hospital ward for blacks, about eight months after being diagnosed with cervical cancer; never knowing that her cells would become one of the most vital tools in modern medicine and would spawn a multi-billion dollar industry where her replicated cells would be bought and sold by the billions.

http://www.todayifoundout.com/index.php/2010/05/there-was-once-a-woman-who-had-immortal-cells/

Itmakes me think that the human body is capable of pretty much anything. But also that this womens cells has probably saved millions of lives and yet ive never even heard of her.
 
a multi-billion dollar industry where her replicated cells would be bought and sold by the billions.
She was survived by her husband and five children, the surviving members of which still to this day live in poverty (one who is homeless on the streets of Baltimore) and were long ignorant of the importance of Henrietta’s cells to modern medicine.

wow shocking... someone is making a nice fat profit off her cells and her family never saw a cent rofl
 
i'm not sure there is anything specifically amazing about that, is that not just cancerous cells?

50 million tons of her cells are alive today

her immortal cells have been essential in curing polio; gene mapping; learning how cells work; developing drugs to treat cancer, herpes, leukemia, influenza, hemophilia, Parkinson’s disease, AIDS… The list goes on and on and on

They can even be frozen for literally decades and later thawed and they will go right on replicating.

Nearly every lab has some of her cells.

Her cells are a multi billion dollar industry.


Hardly just your standard cancerous cells.
 
When Henrietta’s husband first learned about his wife’s cells, he misinterpreted what the doctor was telling him on the phone due to the fact that he only had a 3rd grade education; he thought the doctor was telling him that his wife was still alive and scientists had been keeping her in a laboratory for the last 25 years and using her to experiment on.

:o

And from wiki

Mrs. Lacks was buried without a tombstone in a family cemetery in Lackstown. Her exact burial location is not known, although the family believes it is within feet of her mother's gravesite.[

:(
 
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hmm why doesn't someone who is experimenting with her cells have the decency to take her kid off the street...you never know she may have passed off something interesting to him/her.
 
I wonder if this meant she was more vulnerable to cancer. The signs seem to be there at least.

Can any biologist spread any light?
 
i'm not sure there is anything specifically amazing about that, is that not just cancerous cells?

Yes, it was with this that cell biologists found that cancerous cells had lost the ability to die, and therefore could be used for research and the recombinant protein production in cancerous mammalian cells that we use today in process engineering.

I wonder if this meant she was more vulnerable to cancer. The signs seem to be there at least.

Can any biologist spread any light?

She had cervical cancer, it was the extracted cancer cells themselves that were cultured because they discovered that cancer cells (any cancer cells, not just these in particular ones) have lost the innate ability to die. It's just that if they hadn't have taken a sample from her, then the discovery may not have occurred so early!
 
She had cervical cancer, it was the extracted cancer cells themselves that were cultured because they discovered that cancer cells (any cancer cells, not just these in particular ones) have lost the innate ability to die. It's just that if they hadn't have taken a sample from her, then the discovery may not have occurred so early!

I read the OP too Dave, thanks all the same.

My point was more driving at whether the immortal cells actually increase the incidence/liklihood of cancer. From my understanding, cancer tends to be when the cell's replication function malfunctions - so to speak - and thus leads to tumors. If the cells are immortal and constantly replicating, does this increase the obvious risk of cancer or are they statistically better to have than normal cells which die?

EDIT:

Perhaps too brash. I've re-read your post, so allow me to back up slightly: All cancer cells have lost the ability to die? There's nothing special about this woman's normal healthy cells (I must admit I wondered if this was the case, would she ever age!)?
 
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I read the OP too Dave, thanks all the same.

My point was more driving at whether the immortal cells actually increase the incidence/liklihood of cancer. From my understanding, cancer tends to be when the cell's replication function malfunctions - so to speak - and thus leads to tumors. If the cells are immortal and constantly replicating, does this increase the obvious risk of cancer or are they statistically better to have than normal cells which die?

Aha too late - I thought maybe it was a case of TL;DR :D

As far as I understand it, the only "immortal" cells in her body were the cancerous ones - that is to say that the 'normal' cells were themselves mortal and not immortal. I'm no biologist (far from it) but as I understand from working with carcinoma cells, cancer cells undergo uncontrollable replication and have lost of the inherent ability to die, due to a genetic mutation caused by a number of factors. Thus the presence of the immortal/cancer cells in her body will have lead to an increased risk of tumours as they have the conferred ability to replicate uncontrollably, creating more cells rather than simply replacing.

I wouldn't say that they are better to have than normal cells though - the mutation of the genome would invariably mean that the cell loses some ability to do other things that are vital for the viability of the organism as a whole. When normal cells lose are stressed or cannot function properly, they undergo apoptosis (essentially, committing suicide) and so they can be replaced by genetically-correct cells - cancer cells tend to block the signals for apoptosis and thus the body cannot replace the mutated cell with one needed for normal functioning.

EDIT:

Perhaps too brash. I've re-read your post, so allow me to back up slightly: All cancer cells have lost the ability to die? There's nothing special about this woman's normal healthy cells (I must admit I wondered if this was the case, would she ever age!)?

Just spotted the edit, I'm too slow typing at this time! Yes, that's how I understand it. It's not quite Benjamin Button :D
 
Ah I see. So, there's nothing abnormal about this woman, merely that she's the case-study and original reference for the study of cancerous cells. A little less extraordinary I suppose, but interesting nonetheless!

So in answer to the first point: that would be a 'yes' as by definition such cells are cancerous! :o

Well, I've learnt something new already today and it's only 2am. Go me.
 
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