If I rest my pink on the desk it "sticks" to the desk surface stopping the mouse from moving smoothly.
Never ached with it, but.. I normally use my first two fingers on the main buttons, and don't use my middle finger for the roller, I use my 2nd finger instead. So my pink actually rests against the desk. I were to use it in as a 3 button mouse and use 3 fingers on (middle finger on roller), then it would feel unnatural to me, and perhaps make it ache. But never had an issue personally.
That costs money and Im cheap, gonna wear a glove instead![]()