Yep, did a similar trip to Mr Fox there last year and as he says a week is far too short. With flight times and time difference you only really have 5 full days there which is maybe enough to do LA and the surrounding area/attractions.
If you can afford it, do two weeks and start in San Francisco then drive to Yosemite Park, back out to Pacific Coast Highway and down to LA. Then end up in Vegas. Here is my thread on our trip in which we did just that from last year:
http://forums.overclockers.co.uk/showthread.php?t=18131244
The itinerary was:
Arrive SF, eat, crash out after 20+ of being awake and travelling!
Day 2 in SF- Alcatraz, tram ride + shopping
Day 3 in SF- Free time- do touristy stuff
Day 4- Pick up car, drive to Yosemite Park, look at big trees, waterfalls and mountains then head down to Oakhurst for the night. Long day of driving but the only way we could do it.
Day 5- Drive to Monterey. Check out the Aquarium and Cannery Row
Day 6. Still in Monterey, do 17 Mile Drive, have lunch at Pebble Beach and check out Carmel.
Day 7. Drive through Big Sur to San Luis Obispo and stay at the Madonna Inn for 4 July!
Day 8. On to Santa Monica. Check out Venice Beach/ Santa Monica Pier
Day 9. Sightseeing on a tourbus in LA
Day 10. Sightseeing on tourbus in LA
Day 11. VEGAS BABYYYYYYY. Drive up to Vegas and hit the gun store en route
Day 12. Canyon South Rim. Gotta be done.
Day 13-16 More Vegas shenanigens!