It shouldn't effect anything - other than an overclock as mentioned as you usually have to sacrifice a couple of 100 MHz or more to keep things stable (extra stress on the memory controller).
But even at stock you 'may' have to tweak a few settings to get 6 sticks stable - but that's not unusual or anything ot worry about (again due to the extra stress filling all 6 slots).
I know the memory controller being on the CPU (1366) didn't make it so much of an issue (compared to the MCH on the on the MB) but that's a mighty clock with 6 sticks - were you able to slot them straight in or did you have to tweak?
I know of a few other members who initially thought they had lost their maximum clocks - but then found 'creative' tweaks to get things stable...
It proved to be a big bonus, for clockers, to move the controller from the MB to the CPU.
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