Yeah it was harder to get into my current job with the 2:2. I overcame that by taking a pro-active approach. I arranged a pre application tour where I got to know the people I would be working with and people who were going to be on the interview panel. They remembered me and how well we got on, which became the deciding factor in me getting the job.
During the interview I was asked why I had straight A's at A-level and only got a 2:2 at degree. I did have some mitigating issues at uni which was the main reason for my under achievement, I explained this and it seemed to go down well with the panel.
Luckily I did my degree at a good Russell group university, which does carry some weight when compared to people with a 2:1 and above from a non-russell group uni. This may not be true in all cases, but it certainly has been for me.