There is very little difference when using 4 sticks instead of two, but you may find you need a slight increase in voltage for the CPU to stay stable as the memory controller is on the CPU and more modules means more strain on the processor.
You can only increase the BCLK by one or two before the OC becomes unstable. There is no noticeable speed increase as the core speed is increased only by about 0.5GHz.
Due to the very small increments the base clock can be increased by, it is very unlikely for you to experience any issues involving RAM.