It has its quirks, but as mentioned you NEED a fast quad and at least 1gb vram to run this game at 60+fps, I think even the 'official' recommended specs state that a 2.5ghz quad is required.
Yes it runs your other games fine and maxed out, but this is not 'other games' and this is also a different engine, that depends on processing power more than anything.
Its also hardly a poor console port either, most 'poor' console ports you wont see a major change in the graphics from 360~PC. Yes it could be better, but there are plenty of console commands to help improve things, which lets be fair are PC exclusive and rockstar should be given credit for.
Bottom line: Go OC your chip to 3+ghz (should be more than achievable), maybe throw another 2gb of ram in and then test it out.
Also for your crossfire issues (which I have my self, run the game with 1 card as the fix doesn't work for me) try entering the launch command of -norestrictions