This is true as i have a 2560x1440 screen and 3x 470's which only have 1.2gb of vram so asking this fourm that would never work due to lack of vram......
But currently rocking all settings on High with no AA hovering arounf 100fps and never going below 60
The reason i run high is i personally cant see much diffrence for the frame rate hit at this res brings it down to 20-40fps to some people playable but not for me As the game looks great on high with FXAA and is smooth as silk and trust me i know when a game is stuttering and laggin and i can not stand it hence the need for such high frame rate