I'm running a Silver Arrow on an Asus P8P78 Pro, which looks to have similar enough arrangements to be comparable. The Silver Arrow doesn't interfere with the graphics card at all, but one of the fans does overhang the first couple of RAM slots. This seems be a common situation for most motherboards - GPUs are fine, RAM is affected.
If you are running RAM without heatsinks, or with low profile heatsinks (XMS3 for example), you will be fine. I am running RipjawsX which have quite high profile heatsinks, so I had to raise one fan to clear them - which then meant I couldn't fit the side of my case on.
Rather than change RAM, I simply switched the fans from in front of the heat sinks, to behind them - in effect changing from a push-push config to a pull-pull. Some people say the difference can be a degree or two, but as my cores all stay 50-60 under Prime95, I don't think the effect is too great. Again, this is a very common approach taken with this cooler and high profile RAM.
I would say check the cooler will fit in your case (it only just clears my side, and I don't know the clearance difference between our cases) and, assuming it'll fit, get it - it's awesomely cool-running and ridiculously quiet too.