Picked this up in the Steam Christmas sale.... I'm hooked - I never thought driving the Intercity 125 from Paddington to Reading would be so interesting but looks like I've awakened the child inside me that wanted to play with trains all day long 
Anyway my system spec is in my signature, I'm not running the game with TSX enabled at the moment as it crucifies my frame rate which drops to around 20fps with MSAA x 4 and ingame settings on high except for shadows which are on medium.
Anyone else running the game with a Radeon card care to share their wisdom (and settings)? I will add more detailed results and my settings this evening.
*edited@18:45 on 16/01/2012 - Well after much playing around, reading forums and googling for answers I found out what kills the frame rate in Railworks 3 (Train Simulator 2012) - it seems on my system at least that when TSX is turned on the Shadow Quality setting can kill performance! I did numerous benchmarks which are included below - I can flesh them out with more detail if requested (I haven't run all tests at all MSAA levels etc). Most of the advanced graphics settings (accessed ingame) only contribute to frame loss in single figures however the Shadow Quality setting can reduce frame rate by double figures and appears to have a castrophic effect on minimum frame rate. Looks like it requires a fix from the software vendor, lets keep our fingers crossed...
All benchmarks/testing was performed with the following software/hardware:
AMD Catalyst 11.12
Fraps Version 3.2.3 Build 11797
Windows 7 x64 Home Edition
i5-2300 @ 3.3GHz (multiplier @ x33)
Sapphire ATI Radeon 5850 1Gb - Reference Architecture
Gigabyte GA-Z68X-UD4-B3
4GB (2x2GB) OCZ PC3-12800 Low Voltage Edition
Railworks 3 (Train Simulator 2012)
The scenario chosen was Autumn Leaves from the Oxford-Paddington FGW line. The test was started from the sidings and finished in the station after the FGW InterCity 125 had arrived at the platform with various different cameras and angles being used throughout. Lights and wipers were also switched on (to display TSX features).
Default Graphics Levels
The following graph was produced by utilising the default/basic graphic levels from within the ingame menu (instead of using custom level), this is probably where the problems could have been reduced if the vendor had set the shadow quality setting based on the actual performance hit. I also used these benchmarks to compare performance between TSX=Off and TSX=On.

Custom Graphics Levels
After deciding that I needed TSX on the following benchmarks have it selected. After having an idea what the problem could be with a low frame rate when TSX is enabled (Shadow Quality), I set about trying different custom graphics levels to see if I could increase framerate!

I then decided to turn bloom and depth of field back on to add to the immersion and find out what hit they had on performance. You can clearly see the performance hit from enabling even low shadowing here.

Now I just need to decide if I want bloom/depth of field or high quality shadows...... to remain with a nice minimum frame rate.
Cheers

Anyway my system spec is in my signature, I'm not running the game with TSX enabled at the moment as it crucifies my frame rate which drops to around 20fps with MSAA x 4 and ingame settings on high except for shadows which are on medium.
Anyone else running the game with a Radeon card care to share their wisdom (and settings)? I will add more detailed results and my settings this evening.
*edited@18:45 on 16/01/2012 - Well after much playing around, reading forums and googling for answers I found out what kills the frame rate in Railworks 3 (Train Simulator 2012) - it seems on my system at least that when TSX is turned on the Shadow Quality setting can kill performance! I did numerous benchmarks which are included below - I can flesh them out with more detail if requested (I haven't run all tests at all MSAA levels etc). Most of the advanced graphics settings (accessed ingame) only contribute to frame loss in single figures however the Shadow Quality setting can reduce frame rate by double figures and appears to have a castrophic effect on minimum frame rate. Looks like it requires a fix from the software vendor, lets keep our fingers crossed...
All benchmarks/testing was performed with the following software/hardware:
AMD Catalyst 11.12
Fraps Version 3.2.3 Build 11797
Windows 7 x64 Home Edition
i5-2300 @ 3.3GHz (multiplier @ x33)
Sapphire ATI Radeon 5850 1Gb - Reference Architecture
Gigabyte GA-Z68X-UD4-B3
4GB (2x2GB) OCZ PC3-12800 Low Voltage Edition
Railworks 3 (Train Simulator 2012)
The scenario chosen was Autumn Leaves from the Oxford-Paddington FGW line. The test was started from the sidings and finished in the station after the FGW InterCity 125 had arrived at the platform with various different cameras and angles being used throughout. Lights and wipers were also switched on (to display TSX features).
Default Graphics Levels
The following graph was produced by utilising the default/basic graphic levels from within the ingame menu (instead of using custom level), this is probably where the problems could have been reduced if the vendor had set the shadow quality setting based on the actual performance hit. I also used these benchmarks to compare performance between TSX=Off and TSX=On.

Custom Graphics Levels
After deciding that I needed TSX on the following benchmarks have it selected. After having an idea what the problem could be with a low frame rate when TSX is enabled (Shadow Quality), I set about trying different custom graphics levels to see if I could increase framerate!

I then decided to turn bloom and depth of field back on to add to the immersion and find out what hit they had on performance. You can clearly see the performance hit from enabling even low shadowing here.

Now I just need to decide if I want bloom/depth of field or high quality shadows...... to remain with a nice minimum frame rate.
Cheers
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