-4 sounds too much. How much castor? Does it have that much roll that it's going to get the tyre flat?!
The edge differences could be toe induced scrub which will feather away the edges. Once camber wears a tyre into a cone it then tends to stay that shape and wear evenly.
My fronts are -1 deg rears -2. The rears wear dead flat with zero toe then front wear on the inside edges.
My tyres will be F1AS2. I'm hoping it's ok but who knows, it's not going to be 25C at least, its likely the rears will overheat so need to work on starting pressures. The goodyears are a softer sidewall so ill wind the konis up to max, even then I'm slightly worried about how it's gonna feel
But i guess at least I'm ready for rain

. I had RE050As then the S001s before, the S001s worn quicker but were better in wet. Both were better on a dry warm day than the goodyears, both feel and grip and felt confident to press on just not as much in wet. the f1as2 are opposite, great in wet and crap conditions but a bit vaguer in the dry.
The above is relative though. Both are miles better than something like T1Rs and my car is very sensitive to tyres, exaggerated by the poly bushes.
Oh and S001 will probably be my next 'set of four' tyre. At the moment I think I need to replace the fronts before the rear on a RWD:s. need the get the alignment checked (WIM fast road settings at moment )