Ive got a GS300 with 95k now... few points:
1. Fuel pump failed, covered by Lexus under approved warranty
2. Soft suspension, bottoms out with a full load on sweeping roads, exhaust got ponged, covered by Lexus warranty
3. Poor on the corners of course (came from the 335i) but as a comfy cruiser it is superb (it does go round corners)
4. Very comfy, great leather seats vented and heated
5. Feels nothing like its age or miles to me
Overall, i found it a great car for the money. Now its time to change but I cant find anything that really comes close for the money. So well kitted out for a 2005 car.
I understand the 450h can have a number of issues with the battery, but its hard to quantify how common it is. Just have a search.
Id also consider a GS300. I chose it over the 450h at the time due to it being reasonable power and economy without the slight fear factor over the battery pack. Additionally the boot is bigger and ive heard mixed economy reports from 450h owners. For note I average 30mpg from mixed driving in the 22k miles or so I've done this year.
As a sub 10k car, it think they are great bargains.