It won't deviate massively from the comic in direction. We already know the current 'problem' being faced in the comics will come into the TV show in later seasons.
They've had a different showrunner for each season now. yet direction has relatively played out like the comics, more so since Darabont left.
Kirkman (Creator & Writer of the comic) is still captain of the ship and will no doubt decide on key factors of change.
The best part of the TWD as a tv show is, that basically they don't have to worry about the overall direction, that's mapped out with 106 issues (So far, and appears not to be letting up in the slightest) of intense story, you're not even half way through the comic story in terms of the tv show. All that remains is the flesh out of the details in-between, which they've handled quite well up til this point with additions like Daryl and slight changes to events that make them different, but with a similar outcome.