At low settings and with some hefty frame rate drops maybe but its not a very good experience at all.
@DJ Bucho- It is one of the better examples of Physx and for me makes the game look a lot better. I played it with 7970 crossfire and with 780 SLI and preferred the latter as the eye candy is a lot nicer. Lots of nice effects on liquids and sparks/explosions
I'm running an AMD FX-8250 @ 4.2ghz, and an Asus 7970 matrix Platinum, as default my PhysX option is set to 'Low', if I set it to 'high' I get a definite drop in FPS, and the movement definitely feels more sluggish

So I followed the steps about changing the PhysX option within the WillowEngine.ini file. it didn't seems to make any difference to be perfectly honest and whatever I changed it to, when I loaded up Borderlands it was still set as low

So I made sure both where set to high (the option was set to '2' in the WillowEngine.ini file) and the in game PhysX option was set to 'high', then rebooted my machine. BOOM!!! The game runs just as smoothly as it did with PhysX stet to low, but now PhysiX is set to high in game. AWESOME guys, I'm loving this, it's bloody brilliant. I'm off to blow some stuff up and look at all those extra particles, WHOOP WHOOP

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