nVidia is mostly moving PhysX functionality into the GameWorks library under FleX implemented using Direct X rather than CUDA (which runs on AMD GPUs though how well it performs is another matter) so future titles will be generally using that if anything rather than GPU PhysX.
The VRAM use is a bit of a mixed story - I'm using a 2560x1440 monitor (ROG Swift) with both a 780 and 970 to hand and there aren't that many games that actually use over 3GB - a lot of games with ultra settings (using the same settings on both) sit at 28xxMB used on the 780 and 34xx-36xxMB on the 970 with absolutely no impact on performance, smoothness or visual quality on the 780 (so largely the extra is probably cached data) - whereas at 4K the VRAM use would push past 3GB on the 780 and even ignoring the core performance make it struggle badly. That said the actual payload isn't that far from 3GB at ultra settings with some games so I'd definitely want a decent bit of headroom if I was upgrading - preferably above 4GB.
The VRAM use is a bit of a mixed story - I'm using a 2560x1440 monitor (ROG Swift) with both a 780 and 970 to hand and there aren't that many games that actually use over 3GB - a lot of games with ultra settings (using the same settings on both) sit at 28xxMB used on the 780 and 34xx-36xxMB on the 970 with absolutely no impact on performance, smoothness or visual quality on the 780 (so largely the extra is probably cached data) - whereas at 4K the VRAM use would push past 3GB on the 780 and even ignoring the core performance make it struggle badly. That said the actual payload isn't that far from 3GB at ultra settings with some games so I'd definitely want a decent bit of headroom if I was upgrading - preferably above 4GB.

