Not initially. The Wing plant is very good at what it does, but I can imagine with Airbus being part owned by Germany and France and UK not owning a share any longer, long term they may want to bring that work back to the continent if they have a say in it. But just a guess on my part.
Rolls Royce who provide most of the engines on the A380's / A330CEO NEO and A350 should still be okay producing there engines down in Derby as that is not quiet easy to replicate. But then again they do have a new testing facility planned for Derby, but was on hold last I recall to see how Britexit panned out.