Sound cards and SATA/USB controller cards can use them.
In case of PCIe v4.0 x1 slot would actually have bandwidth for quite a lot, but only X570 boards have it.
Previous AM4 boards use dozen years old PCIe v2.0 with only 500MB/s of bandwidth, which can be saturated by single SATA SSD.
For mechanical drives that would be quite good for two channels SATA controller.