Most people’s first time going to Tokyo they want to stay central and naturally they think Shinjuku is central or they think Shibuya (crossing) is central but in actual fact that’s not strictly correct. Tokyo has a circle line like London call the Yamanote line, and the middle of that is Raponggi Hills, a popular ex-pat area since there are lots of Embassy there. But in actual fact, most of the popular districts to visit in Tokyo is on the Yamanote Line, so if you stay on a station near the Yamanote Line, you are fine. Shinjuku is on the west side, Akihabara is on the East side, as is Asakuka also on the east side. Tokyo Skytree is north east, Ginza is south east, the fish market too is on the east side. There are actually more interesting things on the east side (IMO) than the west side where Shinjuku is. Also, if you are getting on the Shinkasen, they all starts at Tokyo Station, which is on the east side, and if you go to Osaka, it goes south for a little bit on the same line as the Yamanote line before leaving the centra Tokyo area. Meaning it is more convenient really to stay on the east side. Ueno is a nice place, Asakusa is a more old school Tokyo area and accommodation there is cheaper.