Hey I saw the KEF logo and suddenly sat up in my chair, scrolled up and saw the NAD D 3045 and had to stand up in excitement. You are in for a treat. KEF's Uni-Q drivers are supremely matched with NAD's sound signature. Fire up your favourite vocalists when you've got everything set up and you'll be in musical heaven for hours.
Aside from that, games and media sound superb too. Playing God of War currently and when the dragon speaks etc it's a deep rumble you can feel in your chest. I have the Q300 speakers so yours should sound similar although the bass reflex port on mine are front firing and I've not heard the 350s so not sure what difference the port location makes on these cabinets.
Anyway, you're in for a treat. On the 3045 make sure to not accidentally press the BASS/EQ button that changes the frequency output as you then need to cycle through them to get back to the default off state. It's not obvious you've pressed said button and the sound will get worse as certain frequencies are offloaded for output to a subwoofer etc which is of no use if you've not got one connected. Once you cycle through to "HP 40Hz" on the display, press it once more and that's back to the default mode then.
Also, having owned the D 7050 before the 3045, the 7050 did not have a dim display mode or display off mode button, always make use of the dim mode or manually turn the display off with the button. The VFD/OLED display will burn in after a couple of years if the bright mode for the display is used often. It's nothing major but looks annoying as you can see the weaker pixels when adjusting volume etc.
Don't think it matters on these NADs as the circuitry is lifted off their high end Master series amps. Really clean and direct sound.