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I believe some B450 Mobos halve their GPU PCIe slot speed when using the second M2 NVMe slot.
So it'll be running PCIe 3.0 x 8. This could have an impact on this GPU as you've lost 87% of the PCIe 5.0 x 16 bandwidth.
Seen as they lost performance after installing their NVMe, I'd hazard a guess PCIe 3.0 x 8 isn't sufficient bandwidth and is limiting the card.
Asus state this in their B450 Strix-I manual for their PCIe speeds. Note the only x16 on this board is the GPU, the others are x4.
"AMD B450 Chipset- 4 x SATA 6Gb/s ports* The M.2_2 slot shares bandwidth with PCIE x16. When M.2_2 slot runs in PCIE mode, the PCIE x16 slot will run at x8 mode.
** The M.2_2 slot is not supported for these CPUs."
If this is truly the case (will find out later tonight) then I think I'll throw in the towel and go AM5.