COVID-19 (Coronavirus) discussion

[VincentHanna]

What a weird poster.

Anyway, I don't even know if it is Covid, but it's messed me up to be honest, I think it's given me some weird Insomnia as I've only slept for about 4-4.5 hours for the past 4 nights. I don't usually have an issue sleeping.

 

[edscdk]

There is a lot more resistance to Covid. Largely thanks to the early distribution of vaccines

i believe it's because everyone has had covid several times and has natural immunity. Mrna vaccines for covid i believe were a mistake (and should have only been given to the most vulnerable) , they only prime the immune system to a small part of the virus and the way it works means you can get 10% of the dosage or 1000% of the dosage.. if id know before when i know now i would never have taken the vaccine

 

[edscdk]

Different people seem more or less susceptible to different variants so might have got lucky that way - some of my acquaintances were getting it repeatedly when Delta was going around but seem immune to later variants, I was almost certainly exposed several times to pre-Omicron variants without symptoms but then got hit by Omicron.

i watched a poop ton of immune system videos, its a fascinating thing, you are immune to everything to some degree its just some stuff might overwhelm the initial immunity and kills you (so a vaccine primes your system to build more defences against that 1 thing)..

 

[Tephnos]

i believe it's because everyone has had covid several times and has natural immunity. Mrna vaccines for covid i believe were a mistake (and should have only been given to the most vulnerable) , they only prime the immune system to a small part of the virus and the way it works means you can get 10% of the dosage or 1000% of the dosage.. if id know before when i know now i would never have taken the vaccine

Yeah, no.

The vaccines primed the immune system, because T-cells are more encompassing and were able to recognise the virus quicker in those who were vaccinated. The vaccines targeted the small part of the virus because that part is the one that actually attaches to cells and infects them. If they had needed to, they would have targeted more of the virus.

You are also not 'immune to everything'. The whole reason you build a defense against something is the body has to first recognise there is an invader and mount a response. Some viruses are incredibly good at dodging this mechanism of our bodies, and when a virus can rapidly cause damage because it gets a good few extra days before your body can do anything, it's not a fun time.

 

[Werewolf]

i believe it's because everyone has had covid several times and has natural immunity. Mrna vaccines for covid i believe were a mistake (and should have only been given to the most vulnerable) , they only prime the immune system to a small part of the virus and the way it works means you can get 10% of the dosage or 1000% of the dosage.. if id know before when i know now i would never have taken the vaccine

All vaccines (and indeed the immune systems natural response) only respond to a small part of the virus, because that's the unique part of the virus.

It's a bit like you don't need to know every detail of a car, to tell you to get out of the way of the car that is heading towards you, and you don't need to know the vin number of the car to know that it was a red Mini that hit you.

The dosage is very carefully controlled, it's a basic part of the QC and one of the things they are really, really good at doing. Ironically MRNA vaccines are probably much easier to control the dosage on than many of the "traditional" ones, as every step of the production is fully under the control of the scientists and engineers who developed and made it, unlike say inactivated vaccine where you take a live viral load then try to damage it just enough that it is still recognisable to the immune system to get a response but not able to replicate, let alone the oldest types.

 

[edscdk]

You are also not 'immune to everything'. The whole reason you build a defense against something is the body has to first recognise there is an invader and mount a response. Some viruses are incredibly good at dodging this mechanism of our bodies, and when a virus can rapidly cause damage because it gets a good few extra days before your body can do anything, it's not a fun time.

I trust these guys' videos

 

[edscdk]

All vaccines (and indeed the immune systems natural response) only respond to a small part of the virus, because that's the unique part of the virus.

It's a bit like you don't need to know every detail of a car, to tell you to get out of the way of the car that is heading towards you, and you don't need to know the vin number of the car to know that it was a red Mini that hit you.

The dosage is very carefully controlled, it's a basic part of the QC and one of the things they are really, really good at doing. Ironically MRNA vaccines are probably much easier to control the dosage on than many of the "traditional" ones, as every step of the production is fully under the control of the scientists and engineers who developed and made it, unlike say inactivated vaccine where you take a live viral load then try to damage it just enough that it is still recognisable to the immune system to get a response but not able to replicate, let alone the oldest types.

from my understanding, the MRNA vaccine tricks your body into making the protein that primes the immune system, which is different from how normal vaccines work. The dosage you are injected with might be the same, but your body's response can vary; some people can make hardly any, while others too much

 

[Tephnos]

I trust these guys' videos

It's an oversimplification. You cannot be 'immune' to every disease because otherwise diseases like HSV or HIV wouldn't exist that can target the immune system directly or just straight up hide from it. The immune system does indeed try to mount an immunity response, but certain viruses can just adapt around it completely.

There are also plenty of diseases like measles and such that will completely ruin your health if you catch them, despite the fact your body eventually mounts a response against it. That's why vaccines exist in the first place! There is not a single epidemiologist who will encourage someone to get sick over choosing a vaccine for a good reason.

from my understanding, the MRNA vaccine tricks your body into making the protein that primes the immune system, which is different from how normal vaccines work. The dosage you are injected with might be the same, but your body's response can vary; some people can make hardly any, while others too much

Normal vaccines present the pathogen in an inactivated state, or present a portion of it. The immune system absorbs this and transcribes antibodies for it.

mRNA contains the exact code for the body to produce the antibodies. Studies involving mRNA vaccines of all kinds (including Flu) have shown better immune responses with this method versus traditional vaccines.

 

[Jokester]

Covid mRNA vaccines tell your cells to produce the covid spike protein.

 

[timmothy]

It's still going around in my workplace. The issue is people coming in when they are unwell. It just spreads the bug around and means we all get it.

One man came in with hand foot and mouth disease the other day.

 

[Hagar]

i believe it's because everyone has had covid several times and has natural immunity. Mrna vaccines for covid i believe were a mistake (and should have only been given to the most vulnerable) , they only prime the immune system to a small part of the virus and the way it works means you can get 10% of the dosage or 1000% of the dosage.. if id know before when i know now i would never have taken the vaccine

It is pure coincidence then that 1000+ people were dying each day with many more hospitalised and almost overwhelming the NHS but as soon as the vaccine was allowed to achieve a critical mass in the population, the infection rates and serious fatal incidence dropped right away. I go with the vaccine everytime.
People are now dying from measles because the vaccine rates are too low to ensure that this disease is largely eradicated in the UK.

 

[Infidelus]

The issue is people coming in when they are unwell. It just spreads the bug around and means we all get it.

This ... really annoys me. If you're not well, stay the **** at home or stay the **** away from me! I don't want your germs and if you know you're unwell you should be taking precautions not to infect every other person around you. Selfish ignorant *********!

 

[Rroff]

It is pure coincidence then that 1000+ people were dying each day with many more hospitalised and almost overwhelming the NHS but as soon as the vaccine was allowed to achieve a critical mass in the population, the infection rates and serious fatal incidence dropped right away. I go with the vaccine everytime.
People are now dying from measles because the vaccine rates are too low to ensure that this disease is largely eradicated in the UK.

Personally think it was more complicated than that, the vaccine hitting majority coverage also overlapped with the major change from Delta to Omicron variants in domination and something I think which was misjudged by many people including myself - that it seems that a certain percentage of the population had a higher chance of severe symptoms (additional to those vulnerable due to existing condition) with COVID (to varying extents it is true of most diseases) and that once COVID had worked through that part of the population and they'd either died or survived developing some immunity the situation started to stabilise - which likely also coincided with the vaccine ramp.

While somewhat complicated due to the vaccines being lagged behind changes to the disease I saw a distinct pattern around my acquaintances:

-A subset seemed to get Delta over and over without developing significant immunity which only really changed after they were vaccinated and/or had a case of Omicron.
-Most healthy people the vaccines didn't seem to make a massive difference, the most effective immunity seems to come after a case of Omicron though there seems to be some benefits of Omicron + vaccine - at least around my acquaintances most people seemed to have a moderately heavy dose of Omicron and then very mild cases of COVID after that (those who had Omicron + vaccine seemed to be more resilient against repeat infections compared to those whose immunity came just from Omicron).
-Vaccines did not robustly prevent people being infected and developing symptomatic disease (in their first exposure).
-Vaccines seem to have the biggest benefit by far for those who were vulnerable through existing condition and those with a history of problems with diseases like this were hit hard the first time if not vaccinated - while those who were vaccinated would have a similar severity to healthy people.

 

[UTmaniac]

This ... really annoys me. If you're not well, stay the **** at home or stay the **** away from me! I don't want your germs and if you know you're unwell you should be taking precautions not to infect every other person around you. Selfish ignorant *********!

Absolutely no lessons have been learned from the early days of the pandemic, presenteeism rules the roost to avoid absence reviews and to hell with how many you infect with your germs that may affect others far worse.

 

[tom_e]

One man came in with hand foot and mouth disease the other day.

Caught this off my little one last year, more unpleasant than any dose of Covid I've had

 

[Blackjack Davy]

i believe it's because everyone has had covid several times and has natural immunity. Mrna vaccines for covid i believe were a mistake (and should have only been given to the most vulnerable) , they only prime the immune system to a small part of the virus and the way it works means you can get 10% of the dosage or 1000% of the dosage.. if id know before when i know now i would never have taken the vaccine

Fortunately its not a matter of belief, but straightforward facts.

Ironically MRNA vaccines are probably much easier to control the dosage on than many of the "traditional" ones, as every step of the production is fully under the control of the scientists and engineers who developed and made it, unlike say inactivated vaccine where you take a live viral load then try to damage it just enough that it is still recognisable to the immune system to get a response but not able to replicate, let alone the oldest types.

How lovely that RFK junior is pulling the plug on mRNA vaccine research in the US. What could possibly go wrong?

 

[Hagar]

How lovely that RFK junior is pulling the plug on mRNA vaccine research in the US. What could possibly go wrong?

Due to our governments shortsightedness on funding mRNA vaccine research and development in Liverpool last year, we have little room to criticise.

 

[VincentHanna]

AstraZeneca made $7 billion dollars in net profit last year, and pulled out because Labour ultimately reduced the funding from £90 million of taxpayers money to £78 million.

And it was an "upgrade" to the site, they are still there.

 

[Hagar]

An upgrade that invested in Liverpool with quality jobs and would have extended jobs and plant significantly.

Meanwhile in the southeast...

 

[maschio]

^ "This member limits who may view their full profile."

First time I've see that on the forums but completely unsurprising in this use case. Try and be a better poster and you might not have to hide what you're posting.

This, from the most mentally insane poster on these forums. I'll take that Sir