1 Large M2 NVMe or a 2 smaller drives?

[Typhoon]

Going to be starting a new build for my dad based on a Ryzen 7 3700x and MSI B450 PRO VHD Max.
Is their any difference specifying a single 1TB Samsung 970 Evo M2 NVMe compared to a 970 Evo 250Gb NVMe Boot drive and separate 860 Evo 1Tb 2.5" SSD for storage?

Probably will not use more than 500GB of storage in the life time of the PC so drives are unlikely to approach capacity.

So basically 1 big drive or separate boot and storage drives? Is either option like to cause less slow downs in the future? Difference in cost not an issue.

Thanks

 

[Typhoon]

Thanks guys. Backup are not a problem. He saves everything to OneDrive as well as an external hard drive. So performance wise no difference?

Is a boot drive more likely to fail than a storage drive? If not, the risk of loosing your data is the same regardless of if you have one drive or seperate boot and storage drives. And the risk of any sort of failure/ disruption is double if you have 2 drives rather than one.