Good 2.1 speakers, such as SP2500 or Aego M, will be good all rounders, but primarily they are going to excel when it comes to gaming and movie use, if you're looking for some weight to explosions, etc.
For music though, stereo is always best. So it really depends on what your priorities are, and what desk space you have. You may not have room for larger speakers. If not then the Aego M's will be the ideal choice. Very good speakers and enough cheaper than the SP2500 to make them a better buy in my opinion.
If music is what you're going to use the speakers for most though, then if you have the desk space, bookshelf speakers and a little T amp, would make a great set up; or maybe some powered monitor speakers.