The endurance (TBW - Terabytes Written) differences tend to be obvious if you go to any of those the comparisons sites like geizhals/skinflint.
For instance (4TB, from 5PB endurance, set to only show 2.5" and M.2 and SATA and PCIe (there are quite a few 2.5" U.2 enterprise disks out there too):
so that's 14:4. If you change the TBW to 20PB you only get 5 2.5" drives.
Of course reliability is not only about endurance, but the drive manufacturers certainly mostly build high endurance drive as SATA 2.5". Of course a bigger form factor could allow them to add have more redundancy, but another factor is that for write-heavy drives speed is seldom a factor.
Is your "quite heavily used" write heavy or read heavy? As if it is read heavy then you are probably unlikely to wear out the drives and some of the better NVMe like the Seagate FireCuda, Kingston KC3000 etc., ones are a lot faster.
EDIT: didn't want to link to the spec and price comparers for obvious forum rules, but TPU do have something somewhat similar:
Solid-state-drive database with specifications for products launched in recent years. Includes specs, photos, and technical details.
www.techpowerup.com
not as detailed though. Lot of U.2 drives which really aren't consumer things. As for the lack of details, I guess while the TPU editors and posters are more technical they are not working to get paid with affiliate link commissions like the price comparers do.