Dont know what else to suggest,i feel your pain as this is the worst thing with multi gpus setups,have you tried other drivers,no doubt u have.Just tried bioshock and that still has fps issues. that is an older game though. I need to install better games lol i just cannot be arsed. FEAR 2 is the most recent game i have. And i remember that ran fine with crossfire.
have you tried rivatuner (D3D Overrider) and forced Vsync ,triple buffering ive found that smooths outs some games!
Have you tried to change the catalyst AI from advanced to standard?