If you need a super stable system and can't invest a lot of time for stability testing leaving stock with just elevated powerlevels is best.
Otherwise PBO is sure the way to go. It is more difficult to test and get stable but now with core cycler and other tools it's mostly automated (but time consuming).
There is one PBO in the A.I tweaker and another in advanced tab. They are the same but the advanced tab is the full version of PBO, the one in A.I tweaker is just for powerlimits.
I have the same motherboard and my experience is that the standard VRM frequency is a little bit low for unleashed PBO (I got random idle shutdowns at stock), just increase it to 300 or 350 while keeping an eye on VRM temps.
Otherwise it's not much more than elevate powerlevels and undervolt as much as possible. Try to increase frequency while avoiding clock stretching. it seems like my 5800x want to stay below 70c in single core and 80c in multicore for maximum clocks.
I can help you with the settings, it's a bit complicated until you get the pusslebits together.