64MB cache, 6GB, 10000R, which one is most significant?

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I want to build my first DIY'ed computer system via OcUK, however, I am kinda struggled with this question: which one of these is most significant in improving speed, 64MB cache, 6GB transfer rate, or 10000R HD?

I may probably go for a 950 system with either 1600 or 2000 memory, I just do not want my HD be a bottleneck for my scientific computing and furthermore, I don't have the budget to buy a SSD...

Thanks!
 
Cache is storing data recently used, and oftenly used, so larger can be better.

This drive is what I use (also a version with 6gb/s and 64mb cache) and does a very good job, and an alternative is this one. They're both fine for use, and shouldn't cause a bottleneckl.
 
64Mb cache will give a slight but probably un-noticable real world improvement over 32Mb

6Gbps is pretty much pointless for a mechanical hard disk plus 6Gbps controllers are still pretty immature compared to 3Gbps southbridge based ones.

10Krpm will give better random access speeds than 7200rpm. I'm not sure where the latest VRaptor drives sit in terms of sustained transfers but they're hugely expensive for the capacity they give. For the price of a 450Gb Vraptor you can buy a 64Gb SSD and a 2Tb 7200rpm HDD.
 
As I have both a vrap and a new 64mb WD black I thought I would run some rest. Both connected to my SATA III controller.

WD Black 1tb 64mb
2zexlhg.jpg


Vrap 150gb
2hgz4md.jpg
 
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