Will an 850W EVGA G2 PSU with a OC'd 5820k @4.4, 16GB RAM, x2 SSD's, x1 HD, Nepton 240M AIO, and x4 additional fans run x2 of these cards in Crossfire without getting upset?
You will be right on the limit, but if you run the cards at stock should be OK, if overclocking the cards then I doubt it.