We think we may have found the culprit, all the machines in question have Acrobat updater running in the background so we've had service desk disable it as they find it. Fingers crossed it's that simple!
If its the same 10 people all the time, chances are these people have their old password or something cached or saved somewhere that is automatically trying to login and then locking them out. Check their mail clients or mobiles/iphones etc.
One of our developers found a vbs script that helped find hostnames of computers were account lockouts were occuring. It scanned all DC's for a certain string in the events and gave you the details ... only downside was, it has to be run at Enterprise Admin level
I'll have a look in the morning when I get in and try send it across
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