Another massive difference which is far more important to consider than seals, is that your fridge does not move around over potholes and kerbs and, and get shaken around violently (in comparison) almost every time it is used.
It is the vibration on pipes joints etc that causes minuscule leaks almost constantly on mobile air conditioning systems.
Any kind of fixed installment of air conditioning or refrigeration systems, such as fridges, freezers, office A/C, shop chiller units etc are not allowed to loose any refrigerant gas at all over time, I have seen systems in place for 20+ years and they still have exactly the same amount of gas, to the gram, as when first installed.
However (and I cannot of the top of my head remember the exact figures but I think it's in the region of 10 to 15%) mobile A/C systems such as on vehicles are allowed, by regulations, to loose x percent of their gas each year without it being a concern, because the powers that be, know such mobile systems are subject to huge amounts of vibration fixed systems are not exposed to.
So yes you might be lucky and have a car that looses nothing over a few years, or you may have one that needs topping up every couple of years or so, but unless a major leak is found that looses it all in a matter of weeks, having your system topped up every couple of years or so is normal and not a need for concern.
Don't be silly, I would think the entire refrigerated transport industry would be breaking all the FGAS regulations if this was the case. Most of the smaller systems fitted to vans are similarly connected to car a/c systems but fall under the strict FGAS regs and run on various refrigerants other than R134a.
Sure, a car a/c system is more susceptible to damage because of the reasons you've stated but it isn't the reason to as why it happens. The reason it happens is definitely down to the compressor seals and lack of use to the point they dry up and perish. People don't use their air con in winter, believing that it only serves the purpose of cooling the air in the summer. The lack of use during winter and cold temperature causes liquid migration back to the compressor, this can cause refrigerant absorption into the compressor’s oil and or oil dilution, top this off with the fact that oil will also be stuck in the evaporator with no natural return due to its last use being at a warmer ambient. Ultimately it all leads to less oil on that seal and once a seal has dried out... Refrigerant will slowly seep through the worn seal, its difficult to diagnose as it may only happen when the compressor has generated heat from running. Furthermore, every a/c regas 'rig' isn't accurate enough or given enough time to identify such small leaks.