From a personal computer POV, the biggest concern is malware, so opt for Malwarebytes for Mac. And use an AV if you want to - best case scenario it catches something MacOS related, worse case it prevents you passing on infected files to others.
Xprotect and GateKeeper is fine but unfortunately it can be exploited and bypassed.
If you want to know more then keep an eye on Thomas Reed's twitter and published articles. Plus the MacAdmins Slack (#security channel) has a wealth of info.
As Feek mentions, it's entirely your choice but this is just my two pennies after spending a few years managing Mac's for enterprises.