If you don't know what you'll be using for a RAMDisk, the likelihood is you have no need of it.
I myself have been using RAMDisks for the better part of near two decades. Back in mid 00's SSD's were a lot more unknown on reliability and a RAMDisk where everything was being wrote to would reduce the writes that are used up on the SSD. I have one SSD from way back when now that's still over (I think) 94% fine and that dropped in the end becuase I had retired that SSD to a different system that wrote onto it a lot more afterwards. Otherwise, I typically use RAMDisks because I do image work (mostly photo restoration and recovery) as well as video work (mostly restoration and archival) and in both of these cases you end up doing LOADS of writes (sometimes multiple times of the same thing to try and get a second or more of a cleaner shot), both as backup and as temp files/scratch files. So rather than hit any SSD, I move it all to the RAMDisk instead. Recently, I have also begun to record gaming sessions to provide tutorials on completing quests in games, as well as to make fun videos of stuff in games. Which is better if recorded onto the RAMDisk first, as it's constantly being written onto, then review and archive to storage after once I've made sure I captured what I wanted.
It's also super fun loading up whole games into the RAMDisk, but very few games can actually make loading any faster, because as mentioned earlier in this thread, there are loading bottlenecks where it is not IO limited and thus the amazing speeds and latency with the RAMDisk does not present a faster experience in most cases. Also, most games have outsized typical RAMDisk sizes for the last few years now. The last decade, it was still possible to do something like load up Mass Effect Andromeda into the RAMDisk and run it off there, as it was only 45GB in size roughly. These days, you're looking at 100GB to 150GB in size on average. And very few users will have the necessary 192GB or 256GB of RAM to create a RAMDisk to load in a modern game (and still have enough memory spare) to see if they can get better load times off of them.
The only other thing was of course, for things you don't want touching actual long term storage, so stuff on the RAMDisk is conveniently "lost" if something amiss were to happen, or it's stuff you know shouldn't be kept on long term storage. (Work stuff in particular in certain fields)