are there disadvantages to 2.5" HDD's?

i currently have the seagate drive i posted a link to in my op.
i want to be able to place 2 drives (my current ssd and a mechanical) into my spare 5.25" bay so i can get rid of my 3.5" drive bay to allow for some future plans.

i don't want to lose any performance on the drive and i have found 7200rpm 1tb drives in 2.5" but wanted to know if there are things that could cause a loss of performance that the stats don't show.

alternatively if anyone knows of a adapter that allows for both a 3.5" and 2.5" drive to fit into a single 5.25" bay then let me know
 
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