All major cities in the UK have international airports so I don't really get that point. And it's the same with motorway arguement, in fact it's probably easier to be based in Birmingham or Manchester on that front as your more central and have less congestion (and the associated fees) to deal with?
OK, maybe I should have said major international airports. A lot of international airports in smaller cities either don't fly to certain places, or are overpriced. We live very close to an international airport but the two holidays we had this year (New York and Stockholm) we flew from London airports.
I didn't say anything about motorways, since I know in the midlands there are very good roads linking Loughborough/Coventry/Nottingham/Leicester etc, I'm talking about trains primarily.
Obviously my perspective may be different from other people as I can't drive. A guy I work with can't drive either, but he says that's because when he lived in London you didn't need a car, you could just get the bus/tube everywhere. So he never bothered learning.