E10 combusts differently to “normal” fuel, so that hotter reaction will definitely catch people out this season.
Reading around, it seems that E10 has a lower combustion temperature than straight petrol but that differences in its combustion properties can cause overheating in some engines. This seems to be a problem only in engines that weren't designed for it, though, but on the other hand F1 engines are so extreme that maybe weird things happen. Who knows?