I mean in a case that has not it's airflow setup to match components. Cases out of the box rarely have decent airflow, so we need add fans/change the stock fans to get case to flow the air components need.
What cases are you considering? Maybe you haven't you got that far yet.
Your case has 170mm CPU clearance so will fit almost all coolers, even TRUE Spirit 140 Power would probably fit at 171.2mm (most case specs are conservative).
MSI B450 Tomahawk has plenty of room from CPU toward PCie sockets for even widest coolers, but is only about 50mm center CPU to near side of RAM sockets .. meaning if center CPU to front of fan is more than 50mm it will not fit behind your 43mm tall RAM. At 43mm it is 38mm above top of CPU so top of 140mm fan would be 178mm .. 8mm too tall to fit 140mm fan over your RAM. RAM height is a real problem these days with so much RAM having such tall heat spreaders that are worthless anyway. Testing has shown RAM often runs cooler with heat spreaders removed.
If you could measure center CPU to RAM it would help. Could measure from far side of CPU to RAM and subract half of IHS width.
![Wink ;) ;)](/styles/default/xenforo/vbSmilies/Normal/wink.gif)
If it is 53.2mm TRUE Spirit 140 Power will fit. At about half a 'C' note with a 360w TDP rating it is the best air cooler at very reasonable price. For it prices to up to about £90.