Gentoo, Arch, Linux From Scratch? (j/k)
OpenSuSE gets my vote for n00bs - easy gui install (can be more advanced if you're feeling adventurous), has a decent package manager (with a gui - although when I was using SuSE, I prefered SMART) and looks nice. More importantly though - YaST is a very good configuration tool (again, with a nice gui) - which makes setup and post install configuring easy and intuative for people not used to rooting around in /etc with vi. Also has an automatic update tool (zmd) which work a lot like windows automatic update.
The main issue with the big distros is that they all have their own little scripts to do things and these vary from platform to platform, so if or when you move on to a new distro, you'll find that
some of the "commands" that you're used to are missing (all the basic commands will still be there, of course).
If you have any problems with linux, you can usually find the answer to any problem you come across with the help of mr google: he will become your best friend!
Also -
this has been posted hundreds of times, but is well worth a read.
Best of luck - hope it works out for you.