A build is basically a build, the consideration on 1u and 2u tends to be noise/cooling/clearances/PCIe risers, 3U upwards, it gets easier as you can use full height cards and cooler clearance opens up. The last 3U I did was an old SC833 chassis, MSI x99-A SLI board, Xeon 2620v3 (6c/12t), 16GB and a H200 HBA flashed to IT mode and a Nvidia 210 for display with a dual 5.25 to 3x3.5" Supermicro caddy set-up. That gives 11x3.5" caddies with the slimline ODD & remaining 3.5" bay for SSD's + NVMe on the board. I'd estimate if i'd paid for all of it, i'd owe me just under £300, the board that the case came with offset a decent chunk of that. While the Silverstone above is a nice looking case, but with the $250-300 estimate, it's not cheap. x99 boards seem to be going up in price, but the CPU's are still very decent performers and you can pick up some absolute bargains - even relative to Ryzen if you know what to look for.
