My Gen1 Mille isn't exactly the most uncomfortable superbike around but due to previous injuries and getting older (44 this year) I suffer from sore wrists and back issues when I ride it. As with most superbikes, get it out on the open road at speeds above the national limit and it all starts to make sense and not hurt. Pootle around in town or at lowish speed and that's when I start getting sore.
To that end I'm kinda toying with looking at moving to something less uncomfortable. Something 'supermoto' in style maybe. Or perhaps I'll go back to a BMW, something like an older K1200RS. Maybe a Multistrada? And I've also been looking at Aprilia Shivers and Dorsoduros. Lots of oddball options out there. I'd miss the big Mille like hell but I dunno how much longer I'll manage to put up with the aches and pains!