I have just installed my Zotac Gtx 280 and run 3D Mark 2006 at the standard settings and my scores have not gone up at all from my 8800 GTS 512 mb. To install it I removed physx and the nvidia driver from add/remove programs and then rebooted into safe mode and ran driver cleaner. Then installed the new card and the 181.22 drivers.
8800 GTS:
Overall 13079
SM2 5469
SM3 5655
CPU 3914
GTX 280:
Overall 13361
SM2 5068
SM3 6375
CPU 3890
8800 GTS:
Overall 13079
SM2 5469
SM3 5655
CPU 3914
GTX 280:
Overall 13361
SM2 5068
SM3 6375
CPU 3890