The only time I used brisket is for slow cooked chilli. I remove some of the fat (not all) score it and rub with cumin, chilli, salt, oregano and smoked paprika. I then brown it in a big pot and remove it. Fry some onions and garlic in the pan, add the meat back with 2 tins of chopped toms and a tin of beef stock. Cook that for 6+ hours (longer the better and a slow cooker would be great) at a low heat. Add other bits and bobs as you like. More chilli, beans, hot sauce etc When it is cooked I just rip the meat apart before serving.
I ain't a fan of roasted brisket, people don't seem to cook it long and slow enough to make it nice.