I'll be honest, this is a new one on me
Have tried unplugging my HDMI and moving my mouse around in the area where I knew google maps was or when a game was starting up, and I heard the same noise without the HDMI plugged in.
Tried unplugging all other cables (except for power and ethernet) and still hear buzzing
Seems like its something coming from the PC and interfering with the speaker but not sure what or how its happening
Optical HDMI would have been to isolate the AMP from the source of the interference so I would have put one between the PC and the amp, and possibly another between your PS5 and the Amp, its not impossible the monitors HDMI cable was feeding it back into the amp but it would be less likely imo.
There are also cheap RCA ground loop isolators which would go between any analog source and the amp.
"I heard the same noise without the HDMI plugged in"
Optical HDMI wouldn't stop the noise from the PC but it might stop the amplifier making it worse; there are a lot of wires with a 5.1 system and not all amps are earthed / shielded so theres no guarantee it would stop it completly.
Its probably either the PSU or power circuit on the Mobo or a combination of the two which won't be easy to fault find even if you RMA say the PSU they might not find a fault in the same way people complain about coil whine on GPU's.
installed new CPU, motherboard and PSU
Do you still have the PSU, if you think it was dying then I wouldn't want to risk using it otherwise you could try it instead of the new one and see if you still have the same problem.
If you list what PSU the new one is then I'm sure someone will come along and say whether its considered a good model / brand or one thats poorly thought of but even good models can have the odd bad apple...
You haven't re positioned anything, used a different extension lead etc?
i.e. I know if I leave my mobile too close to the PC / speakers every now and again the amp will pick up interference from it.