Cache or Seek time?

Depends on what your using the drive for.

Cache is important for lots of random writes. Seek time is important for random reads. Seek time doesn't vary much between drives of the same sort of category - it'll be much less for SSDs, less for velociraptors, and more for 5400rpm drives.

If going for storage, probably get the cheapest per gb - there isn't a whole lot of difference in reliability between consumer drives; you'll be better off getting two for a bit more than the cost of the possibly slightly more reliable expensive one, and RAIDing them.
 
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