Apart from the intitial loads, Id doubt you'd ever notice any difference. The reason I know? I was running my games off a 4TB HDD in a external house with other drives and they all loads fine and ran perfect over USB3... so now I'm on super fast drives, apart frm loading in haldf the time, ingame, absolutely no differences whatsoever... but then again I have a load of ram, suppose that could help depending on how much you have.
