I'm also pretty sure that Science has been proved wrong many times.
Science is essentially an iterative process. Yes, it has been proved wrong, but the frequency with which that has happened is decreasing as scientists learn more. There are still huge gaps in "why", but very very few things missing or not understood amongst "what". The macroscopic universe is pretty much sewn up; nearly all of the issues are at the sub-atomic/quantum level, or at the various extremes.
M