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Not had any real issues with crossfire, I have been running my two 5850s for a good 18 months now (got my first one on release week and got my 2nd 6 months later).
keep on top of all the drivers and profiles and you will be ok. However, given the choice i would deffinatly take a single card over two, even if the performance wont be as good. Mainly from a noise perspective (that and sometimes you do get niggles with new games).
I myself will be getting a new single card before the end of january, either an AMD 7970/50 or if they are just too expensive I am very tempted to jump back to the green team for a 580. (the upgrade/new tech itch is very very irritating, especially when you havent bought a new GPU for 18 months)
