Safe is very much a matter of perspective. However with this ram, voltage really is less important and as a result i've not heard of anyone overcooking and melting them (though it's probably possible). Some people seem to be getting slightly better stability at lower voltages despite the fact that you might be able to push them further at higher. I've only had these a month or so, and most of the time i've run them at my boards max which is 3 volts. I strongly suspect it's perfectly safe to run them at 3 volts 24/7 without ruining them (otherwise i wouldn't have done it), but as i've been able to get stability at lower volts, why take the chance?
As far as absolutes go, i'd say you probably can't melt any ram at 2.8v or even 2.9v (except maybe that dodgey batch of Ballistix), but if you can only get stability at more than 3.....then maybe it's not worth it. To be honest though you'll probably find that additional volts with this ram makes very little difference indeed (not nothing, but not much) and if you find something running fine at 2.9v then try running it again at 2.8v then 2.7v.
I haven't actually decided where I want to leave my final overclock, but I suspect that once all is said and done I won't be running my ram so hard that i need more than 2.7 or so.