However strange this sounds I really do love the idea behind it, be it some omipotent power or simple time and space subverting our attempts to do something that could innevitably destroy us or space and time itself.
One of my favorite sets of cooks, The Forever War series by Joe Haldeman, concerns something very similar where the main charcters use relativeistic effects to essentialy travel forward in time, (avoiding spoiling) at which point they get a royal kick up the arse as the universe starts to unravel.