If Molex cable is near front panel connector on card that could bring what ever interference PC's components send into power cabling near signal paths.
Not to mention front panel cabling not being known from EMI protection...
If cable of that Molex is connected to other things power draw of other components causes tiny fluctuations into voltage.
And any longer cable is also antenna for "airborne" interference.
Even human body can do that antenna part:
Touching oscilliscope's probe by finger gives AC frequency received by body.
Also you can make radio with telescopic antenna broken from its base to work by gripping from/touching that remaining stub.
And welcome aboard.
Your first post contained more content than likely half dozen first posts of most newcomers, so you're off to good start.