Get yourself a RTX 2080 Ti to make best use of that monitor. And if you're going for air cooling, look at the Silverstone FT05.
I’m not too fussed about making the ultimate gaming beast just yet, I’m happy with making a solid build. Plus I’m hoping it make decent use of the gsync.
Those vents are pretty big though and they run the full height of the front panel so intake should be fine.
This Gamers Nexus review says that the stock fans are fairly quiet.
https://www.gamersnexus.net/hwreviews/3177-fractal-define-r6-case-review-mid-tower
Would you buy it and just leave the stock fans then, do you think it’ll keep things cool enough?
Edit: The more I’m reading the more I’m seeing custom fan setups and fan controllers etc, pwm fans and other things that I’m not sure about!